This is a bit of a first world problem, but I've noticed that VRChat requires that it be opened on the same monitor as the VR headset. I recently switched to using one GPU for my monitor/Unity windows and a second for just the Rift, but at the moment launching VRChat requires that I plug a second cable from my monitor to the VR GPU, run VRC on it, and then disable the second monitor so that my windows don't open on the VR monitor while I'm using my desktop. Oddly enough, when I disable the VR monitor and VRC's desktop window moves over to the Non-VR GPU monitor, it still seems to run great.

Totally a bit of a fringe case, but if this is something that is easy to do it'd be immensely helpful.